They have taken over production of a rose wine formerly known as Pink Floyd.
The band recorded cult album The Wall at the Chateau Miraval in Correns.
The estate has been the Hollywood couple’s second home since 2008.
The back label of the 2012 Miraval wine, which goes on sale in March, will carry the names Jolie-Pitt and Perrin.
White wines are expected to start arriving later this year.
“They… want to ensure they are making the best Provence wines they can,” Perrin told wine website Decanter.com.
“They were present at the blending sessions this year, and are relooking at everything from the installations in the winery – where we have already switched to stainless steel tanks – to reworking the labels across the range of wines.”
Sting, actors Gerard Depardieu and Sam Neill and director Francis Ford Coppola are among a growing number of celebrities who are involved in the wine business.
The French property, which Pitt and Jolie originally leased for three years, and recently bought, has about 148 acres (60 hectares) of vines.
The chateau, which has been undergoing extensive renovation since it was acquired by the actors, is understood to have 35 rooms and a chapel in its grounds.
Formerly owned by French jazz pianist Jacques Loussier, the recording studio has been used by Sting and the Cranberries, as well as Pink Floyd.