The talk show host was addressing a literary festival Sunday in the northwestern Indian town of Jaipur.
Winfrey praised Obama’s handling of the presidency. She said his next four years would be even more successful, with people able to get back to work.
Winfrey backed Obama during the 2008 presidential campaign in her first-ever political endorsement.
She was among the biggest crowd pullers at the annual Jaipur Literary Festival, which brings together top writers, poets and critics and around 50,000 literary fans from around the world.
Winfrey has been in India for a week filming programs for her new TV network.